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目的探讨非小细胞肺癌(NSCLC)组织3’-脱氧-3’-18F-氟代胸苷(18F-FLT)PET显像所示18F-FLT高摄取区与肿瘤细胞高增殖区的一致性。方法选择12例初治、接受根治性手术切除治疗的NSCLC患者。术前3 d行18F-FLT PET CT检查,以最大标准摄取值(SUVmax)的80%为阈值勾画FLT的高摄取区。术后取得完整的肿块并按在体方向还原,4 mm层厚制作肺癌病理大切片并行HE染色及Ki-67染色,Ki-67指数>20%的区域为高表达区,PET图像与病理图像进行配准后比较高摄取区与高表达区位置是否相同。结果 12例患者成功制作病理切片并顺利阅片。5例18F-FLT高摄取区与Ki-67高表达区一致。结论 NSCLC组织18F-FLT高摄取区与Ki-67高表达所代表的肿瘤细胞高增殖区并非完全一致。
Objective To investigate the consistency of high 18F-FLT uptake region and high proliferative region of tumor cells in 3F-FLT PET imaging of non-small cell lung cancer (NSCLC). Methods A total of 12 patients with NSCLC who underwent initial surgical resection and radical resection were selected. The 18F-FLT PET CT scan was performed 3 days before surgery to map the high-uptake area of FLT with a threshold of 80% of the maximum standard uptake value (SUVmax). After the operation, a complete mass was obtained and reduced in the direction of the body. A large section of lung cancer was made at a thickness of 4 mm and stained with HE staining and Ki-67 staining. The areas with Ki-67 index> 20% were highly expressed. PET and pathological images After registration, the location of high uptake area and high expression area is the same. Results 12 patients successfully made pathological sections and successfully read the film. 5 cases of 18F-FLT high uptake zone and Ki-67 high expression area consistent. Conclusion The high uptake of 18F-FLT in NSCLC tissue is not completely consistent with the hyperproliferation of tumor cells represented by the high expression of Ki-67.