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目的探讨甲状腺功能减退症(甲减)对妊娠期糖尿病(GDM)的影响。方法选择医院妇产科检查并分娩且资料完整的GDM孕妇120例,其中妊娠期合并甲减50例(A组),妊娠期甲状腺功能正常70例(B组),另选单纯甲减孕妇40例(C组)。3组入院后进行常规生化检查[胆固醇(TG)、三酰甘油(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A、载脂蛋白B、肌酐、尿素氮及胱抑素C],比较3组妊娠结局(妊娠期高血压疾病、胎盘早剥、胎膜早破、早产、产后出血、妊娠期贫血、新生儿低血糖、新生儿室息及新生儿甲减)。结果A组中TC、LDL、肌酐高于B组、C组(P<0.05);A组妊娠期高血压疾病和总体不良妊娠发生率高于B组和C组(P<0.05)。结论甲状腺功能减退症可加重GDM孕妇糖代谢及脂代谢紊乱,还可增加GDM孕妇不良妊娠结局的发生。
Objective To investigate the effect of hypothyroidism (Hypothyroidism) on gestational diabetes mellitus (GDM). Methods A total of 120 GDM pregnant women with complete data were selected for obstetrics and gynecology examination in our hospital. Among them, 50 cases were hypothyroidism during pregnancy (group A), 70 cases were normal thyroid function during pregnancy (group B) Example (C group). Three groups were admitted to the hospital for routine biochemical tests [cholesterol (TG), triglyceride (TC), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A, Protein B, creatinine, urea nitrogen and cystatin C were compared between the three groups of pregnancy outcomes (gestational hypertension, placental abruption, premature rupture of membranes, premature labor, postpartum hemorrhage, gestational anemia, neonatal hypoglycemia, neonatal Childhood interest rates and neonatal hypothyroidism). Results The levels of TC, LDL and creatinine in group A were higher than those in group B and C (P <0.05). The incidence of gestational hypertension and adverse pregnancy in group A were higher than those in group B and C (P <0.05). Conclusions Hypothyroidism can aggravate glucose metabolism and dyslipidemia in pregnant women with GDM and increase the incidence of adverse pregnancy outcomes in GDM pregnant women.