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目的探讨大鼠减压应激损伤时大脑和肝胞液糖皮质激素受体结合量的变化。方法大鼠２４只，随机分为５组，置于加压舱内，进行加减压实验。出舱后，以~３Ｈ地塞米松为配体，测定了动物脑、肝胞液糖皮质激素受体结合量的改变，同时还监测了动物心前区减压气泡的变化。结果减压应激损伤后，动物肝、脑胞液糖皮质激素受体结合量均下降，尤其以脑胞液中糖皮质激素受体减少为明显（Ｐ＜０．０１，Ｐ＜０．０５）。动物在高压下暴露时间愈长，脑、肝胞液糠皮值激素受体减少愈明显。这一结果与动物减压后气泡音及ＤＣＳ发病率相吻合。实验还观测到出现减压应激损伤的动物，若不采取救治措施，可随着时间迁移糖皮质激素受体结合量进一步减少。结论脑和肝胞液糖皮质激素受体结合量改变与ＤＣＳ损伤密切相关，可作为评价急性ＤＣＳ损伤的指标之一。
Objective To investigate the changes of glucocorticoid receptor binding in brain and liver cytosols during decompression stress injury in rats. Methods Twenty-four rats were randomly divided into 5 groups, placed in a pressurized chamber, and subjected to pressure and decompression tests. After exiting the capsule, the change of glucocorticoid receptor binding in animal brain and liver cells was measured using ~ 3H dexamethasone as ligand, and the changes of pressure-reducing bubbles in the precordial area of the animal were also monitored. Results After decompression and stress injury, the binding capacity of glucocorticoid receptor in liver and brain cell decreased, especially in the decrease of glucocorticoid receptor (P <0.01, P <0.05) ). The longer animals exposed to high pressure, the brain, liver cells, the value of the reduction of the value of the hyaluronic acid receptor more obvious. This result is in line with the incidence of bubble sounds and DCS after decompression in animals. Experiments also observed that decompression stress injury animals, if not taken to save the treatment, the amount of glucocorticoid receptor binding can be further reduced over time. Conclusions The changes of glucocorticoid receptor binding between brain and liver cytosols are closely related to the damage of DCS, which may be used as an index to evaluate acute DCS injury.