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本文观察了9例胎脑移植患者移植后的一般临床表现(首例移植迄今已有3年零9个月)。测定移植前与移植后外周血中的淋巴细胞计数(Lym)、淋巴细胞转化率(LTT)、血清免疫球蛋白IgG、IgA、IgM,补体C_3、C_4,抗核杭体(AnAb)等常规免疫指标。采用荧光抗体技术检测抗脑抗体。结果:在本组病人中未发现有临床免疫排斥反应(HVGR)和移植物抗宿主反应(GVHR)的临床表现。患者移植前、后的常规免疫指标测定值与正常人对照,无显著性差异(P>0.05)。仅有1例移植前、后抗核抗体均出现阳性反应,但滴度不变,都是1:20。患者移植前、后的荧光抗脑抗体检测也呈阴性结果。因此,初步认为,本组病例的移植免疫效应与“大脑为免疫特免器官”的论点相一致的。
This article looked at the general clinical presentation of 9 patients with fetal brain transplantation (3 years and 9 months after the first transplant). The levels of lymphocyte count (Lym), lymphocyte transformation (LTT), serum immunoglobulin IgG, IgA, IgM, complement C_3, C_4 and AnAb were measured before and after transplantation index. Anti-brain antibodies were detected by fluorescent antibody technique. RESULTS: Clinical manifestations of clinical immunological rejection (HVGR) and graft versus host reaction (GVHR) were not found in this group of patients. There was no significant difference between the measured value of routine immunization before and after transplantation and the normal control (P> 0.05). Only one case before and after anti-nuclear antibody positive reaction, but the same titer, are 1:20. Fluorescent anti-brain antibodies were negative before and after transplantation. Therefore, the preliminary view that the transplant immune effect in this group of patients and “brain immune immune organs,” the argument is consistent.