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观察应用布地奈德、固尔苏配合鼻塞持续气道正压通气治疗新生儿呼吸窘迫综合征的临床疗效。将2006年12月至2009年2月本院收治明确诊断新生儿呼吸窘迫综合征的新生儿62例随机分成两组。治疗组31例:用布地奈德0.25mg/kg和固尔苏(肺表面活性物质)100mg/kg混合液气管内滴入配合鼻塞持续气道正压通气;对照组31例:用固尔苏100mg/kg混合液气管内滴入配合鼻塞持续气道正压通气。观察两组患儿用药前后血气分析结果,以及固尔苏重复使用情况及并发肺炎情况。结果显示治疗组31例中29例治愈,2例改用机械通气,1例合并肺部严重感染,无重复使用固尔苏。对照组31例中22例治愈,9例改用机械通气,7例合并肺部严重感染,重复使用固尔苏6例。说明布地奈德、固尔苏配合鼻塞持续气道正压通气治疗新生儿呼吸窘迫综合征疗效好,减少机械通气,减少重复用药,减轻病人的负担,减少并发症和后遗症的发生,提高患儿的生存质量。
To observe the clinical efficacy of budesonide and celiac in combination with nasal continuous positive airway pressure in the treatment of neonatal respiratory distress syndrome. In December 2006 to February 2009 in our hospital admitted to a clear diagnosis of neonatal respiratory distress syndrome in 62 newborns were randomly divided into two groups. The treatment group of 31 patients: Budesonide 0.25mg / kg and cents Su (pulmonary surfactant) 100mg / kg mixture of intratracheal intubation with nasal continuous positive airway pressure; control group of 31 patients: 100mg / kg mixture of intratracheal intubation with nasal continuous positive airway pressure. Blood gas analysis results before and after treatment were observed in both groups, and the situation of repeated use of Curen and concurrent pneumonia were observed. The results showed that in the treatment group, 29 cases were cured in 31 cases, 2 cases switched to mechanical ventilation, 1 case complicated with serious pulmonary infection, no repeated use of cortisol. Twenty-two of the 31 patients in the control group were cured, 9 were switched to mechanical ventilation, 7 were complicated with pulmonary infection and 6 were treated with Curel. Description Budesonide, Guer Su with nasal continuous positive airway pressure in the treatment of neonatal respiratory distress syndrome efficacy, reduce mechanical ventilation, reduce repeated medication, reduce the burden on patients, reduce complications and sequelae, improve children The quality of life.