解冻周期移植日血清孕酮水平与妊娠结局的关系研究

• 作 者: 史艳彬 佟玉 邵小光
• 机 构: 大连市妇女儿童医疗中心,
• 出 处: 现代妇产科进展
• 发表日期: 2014年10期
• 关键词: 血清孕酮 妊娠结局 流产率 早期流产 生化妊娠 妊娠组 黄体支持 胚胎移植 生殖内分泌 子宫内膜

目的:探讨解冻周期移植日血清孕酮(P)水平与妊娠结局的关系。方法:选取在我院生殖内分泌科自然周期准备内膜的932个解冻周期,其中宫内活胎组348个、未妊娠组(包括生化妊娠)484个、妊娠结局不良组(3个月内流产者)100个。分析患者的移植日血清P水平对妊娠率和早期流产率的影响。结果:宫内活胎组和妊娠结局不良组的移植日血清P水平显著高于未妊娠组[(35.4±21.4)ng/ml、(25.6±19.5)ng/ml vs(18.2±17.4)ng/ml,P<0.05)]。移植日血清P<5ng/ml组和5ng/ml≤P<15ng/ml组的临床妊娠率显著低于P≥15ng/ml组(25%、27%vs 42%,P<0.05)。P<5ng/ml组和5ng/ml≤P<15ng/ml组的流产率显著高于P≥15ng/ml组(100%、46%vs 21%,P<0.05);P<5ng/ml组显著高于5ng/ml≤P<15ng/ml组(P<0.05)。结论:解冻周期移植日检测血清P水平对妊娠结局有一定的预测价值。 Objective: To investigate the relationship between serum progesterone (P) levels and pregnancy outcomes in thawed cycles. Methods: 932 thaw cycles of intima were prepared in the natural cycle of reproductive endocrinology in our hospital, including 348 intrauterine survivors, 484 non-pregnant patients (including biochemical pregnancy), and 4 pregnant women with poor pregnancy outcome (within 3 months) 100). The effect of serum P level on the pregnancy rate and early miscarriage rate on the transplant day was analyzed. Results: The level of serum P in the intrauterine live group and the poor pregnancy group was significantly higher than that in the non-pregnant group [(35.4 ± 21.4) ng / ml vs (25.6 ± 19.5) ng / ml vs (18.2 ± 17.4) ng / ml, P <0.05)]. The clinical pregnancy rates of serum P <5ng / ml and 5ng / ml≤P <15ng / ml were significantly lower than those of P≥15ng / ml on the day of transplantation (25%, 27% vs 42%, P <0.05). The abortion rate in P <5ng / ml group and 5ng / ml≤P <15ng / ml group was significantly higher than that in P≥15ng / ml group (100%, 46% vs 21%, P <0.05) Significantly higher than 5ng / ml