论文部分内容阅读
目的:观察妊娠合并血小板减少的病因及对妊娠结局的影响。方法:选择妊娠合并血小板减少70例作为观察组,根据妊娠期血小板计数减少程度分为观察Ⅰ组(血小板计数<50×109/L)17例和观察Ⅱ组[血小板计数(50~99)×109/L]53例。同时随机选择同期血小板正常妊娠妇女70例作为对照组。观察妊娠合并血小板减少的病因,比较各组妊娠结局。结果:观察组中,妊娠相关性血小板减少症(PAT)、妊娠期高血压疾病(PIH)、特发性血小板减少性紫癜(ITP)、妊娠合并巨幼红细胞贫血(MA)分别占77.1%、8.6%、7.1%和2.9%。观察组阴道分娩率27.1%,显著低于对照组的44.3%(P<0.05);剖宫产率61.4%,与对照组的55.7%比较,差异不显著(P>0.05)。观察Ⅱ组阴道分娩率,显著高于观察Ⅰ组(P<0.05);剖宫产率与观察Ⅰ组比较,差异不显著(P>0.05)。观察组产后出血发生率8.6%,与对照组的2.9%比较,差异不显著(P>0.05);产后贫血发生率17.1%,显著高于对照组的5.7%(P<0.05)。观察组新生儿窒息发生率1.4%,对照组无一例发生新生儿窒息;两组新生儿窒息发生率比较,差异不显著(P>0.05)。观察Ⅰ组产后出血、产后贫血及新生儿窒息发生率与观察Ⅱ组比较,均差异不显著(P>0.05)。结论:妊娠合并血小板减少病因较多,以PAT最为多见,血小板计数减少程度不同,妊娠结局亦显著不同。
Objective: To observe the etiology of pregnancy with thrombocytopenia and its effect on pregnancy outcome. Methods: Seventy pregnant women with thrombocytopenia were selected as the observation group. According to the degree of reduction of platelet count in pregnancy, 17 cases were divided into observation group Ⅰ (platelet count <50 × 109 / L) and observation group Ⅱ (platelet count (50-99) × 109 / L] in 53 cases. At the same time, 70 pregnant women with normal platelet in the same period were randomly selected as the control group. Observe the etiology of thrombocytopenia in pregnancy and compare the pregnancy outcome in each group. Results: In the observation group, pregnancy-associated thrombocytopenia (PAT), gestational hypertension (PIH), idiopathic thrombocytopenic purpura (ITP) and pregnancy-associated megaloblastic anemia (MA) accounted for 77.1% 8.6%, 7.1% and 2.9%. The rate of vaginal delivery in the observation group was 27.1%, which was significantly lower than that in the control group (44.3%, P <0.05). The rate of cesarean section was 61.4%. There was no significant difference between the observation group and the control group (55.7%, P> 0.05). The rate of vaginal delivery in group Ⅱ was significantly higher than that in group Ⅰ (P <0.05). There was no significant difference in the rate of cesarean section between the two groups (P> 0.05). The incidence of postpartum hemorrhage in the observation group was 8.6%, which was not significantly different from 2.9% in the control group (P> 0.05). The incidence of postpartum anemia was 17.1%, significantly higher than that of the control group (5.7%, P <0.05). In the observation group, the incidence of neonatal asphyxia was 1.4% and no neonatal asphyxia occurred in the control group. There was no significant difference in the incidence of asphyxia between the two groups (P> 0.05). The incidence of postpartum hemorrhage, postpartum anemia and neonatal asphyxia in group Ⅰ were not significantly different from those in group Ⅱ (P> 0.05). Conclusion: There are many causes of thrombocytopenia in pregnancy, the most common is PAT, and the reduction of platelet count is different, and the pregnancy outcome is also significantly different.