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目的:研究超常胎盘部位(EPS)的病理特点与临床表现的关系.方法:应用免疫组化ABC法对18例EPS病变进行研究,并结合临床表现进行病理分析.结果:EPS是中间型滋养细胞在胎盘部位非破坏性的浸润肌层和血管壁,而不形成肿块,胎盘泌乳素(HPL)和CK强阳性或阳性,两者细胞定位相同.HCG阳性或弱阳性,与HPL定位一致或不一致.部分病例CEP少量细胞阳性.患者可表现HCG下降缓慢或产后出血.结论:EPS与妊娠有关,蜕膜发育不良或缺如是易发生EPS的条件之一.部分病例有可能发展成PSTT的过渡形式.中间型滋养细胞存在不同亚群,其中一些仍具有向合体滋养细胞分化的免疫表型.“,”Purpose To study the pathological features and relationship with clinical aspects of exaggeratedplacental site (EPS). Methods Eighteen cases with EPS were investigated at the light microscope level and byimmunohistochemical staining and analyzed in combination with clinical symptoms. Results EPS was that intermediate trophoblast (IT) Infiltrated undestructively into the myometrium layers and the wall of the vessel inthe placental site but formed no tumour. human placental lactogen (HPL) and cytokeratin (CK) were stronglypositive or positive expression and both were alike on the cellular location. HCG was positive or weakly positive.The expressed positions of HCG were identical or not with HPL. In a few cells in the partial cases, CEA waspositive. The patient may show slower drop of the serum HCG and postpartum hemorrhage. Conclusion EPSwas correlated with pregnancy. Hypoplasia or absence of decidua was one of easily-happening factors. Some cases may expand into transitional form of placental site trophoblastic tumour. Varying sub-groups of IT exist anddevelop along syncytiotrophoblast with immunohistochemical characteristics.