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目的:探究谷氨酰胺对胃大部切除患者术后血清胃泌素、CA72-4及HIF-1α水平影响。方法:收集我院56例胃大部切除术后患者,随机分为实验组和对照组,各28例。对照组给予临床常规营养治疗,实验组在对照组基础上给予丙氨酰谷氨酰胺注射液100 m L/d。治疗结束后,比较两组患者临床疗效血清胃泌素、CA72-4、HIF-1α及VEGF-A水平。结果:对照组患者治疗后临床有效率71.43%低于研究组患者治疗后临床有效率92.86%,具有统计学意义(P<0.05);对照组患者复发率35.71%明显高于实验组10.71%,具有统计学意义(P<0.05)。治疗后与治疗前相比,患者血清胃泌素、CA72-4、HIF-1α及VEGF-A水平均降低(P<0.05);与对照组比较,实验组血清胃泌素、CA72-4、HIF-1α及VEGF-A水平较低(P<0.05)。结论:谷氨酰胺能有效提高胃大部切除患者术后的临床疗效,防止复发,推测其机制与降低血清胃泌素、CA72-4、HIF-1α及VEGF-A水平有关。
Objective: To investigate the effect of glutamine on serum gastrin, CA72-4 and HIF-1α levels in patients with subtotal gastrectomy. Methods: Fifty-six patients with subtotal gastrectomy in our hospital were collected and randomly divided into experimental group and control group with 28 cases in each. The control group was given routine nutrition treatment. The experimental group was given 100 mg L / d alanyl glutamine on the basis of the control group. After treatment, the clinical efficacy of serum gastrin, CA72-4, HIF-1α and VEGF-A levels were compared between the two groups. Results: The clinical effective rate of the control group was 71.43% lower than that of the study group (92.86%) after treatment, with statistical significance (P <0.05). The recurrence rate of the control group was significantly higher than that of the experimental group (35.71%, 10.71% Statistically significant (P <0.05). The levels of serum gastrin, CA72-4, HIF-1α and VEGF-A in patients after treatment were lower than those before treatment (P <0.05). Compared with the control group, serum gastrin, CA72-4, HIF-1α and VEGF-A levels were lower (P <0.05). CONCLUSION: Glutamine can effectively improve the clinical efficacy and prevent recurrence of patients undergoing subtotal gastrectomy, suggesting that the mechanism may be related to the decrease of serum gastrin, CA72-4, HIF-1α and VEGF-A levels.