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目的探讨中晚期食管癌患者三维适形放疗(3D-CRT)同步化疗的临床效果。方法 60例中晚期食管癌患者,按照不同的治疗方式将其分为对照组与观察组,每组30例。对照组患者给予3DCRT,观察组给予3D-CRT同步联合TP方案化疗。对比两组患者的临床效果、随访后的生存率以及毒副反应发生情况。结果经治疗,观察组临床有效率为86.7%(26/30),高于对照组的63.3%(19/30),差异具有统计学意义(P<0.05)。观察组患者1、2、3年的生存率分别为83.3%(25/30)、66.7%(20/30)、56.7%(17/30);对照组患者1、2、3年的生存率分别为60.0%(18/30)、40.0%(12/30)、30.0%(9/30);观察组1、2、3年的生存率均高于对照组,差异均具有统计学意义(P<0.05)。两组患者均出现毒副反应,但经过积极对症治疗后均可完成治疗,耐受性良好。结论 3D-CRT同步联合TP方案化疗治疗中晚期食管癌患者近期疗效显著,且可提高患者的远期生存率,毒副反应患者可以承受,具有良好的临床应用效果,是性价比较高的治疗方案。
Objective To investigate the clinical effect of three-dimensional conformal radiotherapy (3D-CRT) simultaneous chemotherapy in patients with advanced esophageal cancer. Methods Sixty patients with advanced esophageal cancer were divided into control group and observation group according to different treatment methods, 30 cases in each group. Patients in the control group were given 3DCRT. The observation group was given 3D-CRT combined with TP regimen chemotherapy. The clinical effects, follow-up survival rates and the incidence of side effects were compared between the two groups. Results After treatment, the clinical effective rate in the observation group was 86.7% (26/30), which was higher than that in the control group (63.3%, 19/30). The difference was statistically significant (P <0.05). The survival rates of patients in the observation group at 1, 2 and 3 years were 83.3% (25/30), 66.7% (20/30) and 56.7% (17/30), respectively. The survival rates of patients in the control group at 1, 2 and 3 years Respectively, 60.0% (18/30), 40.0% (12/30) and 30.0% (9/30) respectively. The survival rates at 1, 2 and 3 years in the observation group were significantly higher than those in the control group P <0.05). Toxic and side effects occurred in both groups, but the treatment was completed after active symptomatic treatment and was well tolerated. Conclusion 3D-CRT combined with TP chemotherapy in the treatment of advanced esophageal cancer patients with significant short-term effect, and can improve the long-term survival of patients, patients with toxic reactions can bear, with good clinical application, is a cost-effective treatment options .