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为了研究乙、丙、庚型肝炎病毒感染在原发性肝癌家庭聚集性中的作用，本文应用PCR方法对肝癌病、低发家庭成员进行了HBV-DNA、HCV-RNA和HGV-RNA检测。结果发现，高发户成员和无癌户成员中HBV-DNA和HGV-RNA的阳性率分别为21．8％（12／55）、36．4％（20／55）和7．3％（4／55）、14．5％（8／55）（P＜0．01）。HCV-RNA阳性率分别为10．9％（6／55）和21．8％（12／55）（P＞0．05）。HBV＋HCV、HCV＋HGV、HGV＋HBV、HBV＋HCV＋HGV的重叠感染率分别为3．6％（2／55）、3．6％（2／55）、14．5％（8／55）、3．6％（2／55）和1．8％（1／55）、9．1％（5／55）、1．8％（1／55）、0．0％（0／55），其中HBV＋HGV重叠感染模式两组有明显差异（P＜0．05），其余各模式无明显差异。结果提示，HBV和HGV的感染可能是HCC家庭聚集原因之一，而HBV＋HGV重叠感染模式较其他模式与HCC家庭聚集性关系更为密切。
In order to study the role of hepatitis B, C and G in domestic clustering of primary liver cancer, HBV-DNA, HCV-RNA and HGV-RNA were detected by PCR in hepatocellular carcinoma patients and low-risk families. The results showed that the positive rates of HBV-DNA and HGV-RNA in high-fathers and non-cancer fathers were 21.8% (12/55), 36.4% (20/55) and 7.3% (4) /55),14.5%(8/55)(P<0.01). The positive rates of HCV-RNA were 10.9% (6/55) and 21.8% (12/55) respectively (P> 0.05). The overlapping infection rates of HBV + HCV, HCV + HGV, HGV + HBV and HBV + HCV + HGV were 3.6% (2/55), 3.6% (2/55), 14.5% 55) and 1.8% (1/55), 9.1% (5/55), 1.8% (1/55) and 0.0% (0/55) There was a significant difference (P <0.05), the rest of the mode no significant difference. The results suggest that HBV and HGV infection may be one of the causes of HCC family aggregation, and HBV + HGV overlap infection patterns more closely than other patterns and HCC family aggregation.