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为观察含锗药物9443的放射增敏作用,以小鼠实体肿瘤LA-795肺腺癌研究了9443的放射增敏效果。采用肿瘤生长延缓法评价,测得平均放射增敏比为1.2,药物LD50毒性为5000mg/kg体重。
In order to observe the radiosensitization of the quinone-containing drug 9443, the radiation sensitizing effect of 9443 was studied in mouse solid tumor LA-795 lung adenocarcinoma. The tumor growth retardation method was used to evaluate the average radiosensitivity ratio was 1.2, and the toxicity of the drug LD50 was 5000 mg/kg body weight.