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目的 :为探讨糖尿病肾病 (DN)的早期诊断方法。方法 :用酶联法对 139例 2型糖尿病患者和 40例对照进行OX LDL、TRF及UAER的测定。结果 :糖尿病患者OX LDL和TRF水平显著高于对照组 (P <0 .0 1) ,糖尿病伴肾病患者的水平显著高于无肾病患者 (P <0 .0 1) ;在各组中OX LDL及TRF与UAER有明显的相关性 (P <0 .0 1)。结论 :提示作为DN的早期诊断的指标 ,OX LDL、TRF与UAER具有相同意义 ,并且该两项指标可能较UAER更敏感。
Objective: To investigate the early diagnosis of diabetic nephropathy (DN). Methods: The enzyme linked method was used to measure the OX LDL, TRF and UAER in 139 patients with type 2 diabetes mellitus and 40 controls. Results: The levels of OX LDL and TRF in diabetic patients were significantly higher than those in control patients (P <0.01). The patients with diabetic nephropathy were significantly higher than those without nephropathy (P <0.01) There was a significant correlation between TRF and UAER (P <0.01). Conclusions: Hints OX LDL, TRF and UAER have the same meaning as indicators of early diagnosis of DN, and both of these indicators may be more sensitive than UAER.