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目的 :通过对新生儿缺氧缺血性脑病 (HIE)危险因素及相关因素研究 ,达到早期防治、早期干预的目的。方法 :选择HIE患者 2 13例 ,同时随机选择非HIE患者 6 8例作对照组。从母亲、胎儿、分娩 3个方面 ,列出 2 2个危险因素 ,运用STATISTICA6 0和中国医学百科全书统计软件进行单因素分析及Logistic回归分析。结果 :2 2个变量的单因素分析有 8个因素 (妊娠高血压、胎头吸引器助娩、产程延长、急产、胎粪污染羊水、脐带异常、生后 1minAp gar评分≤ 7分、生后 5minApgar评分≤ 7分 )为危险因素。而把单因素分析有统计学意义的 6个因素 (妊娠高血压、胎头吸引器助娩、产程延长、急产、生后 1minApgar评分≤ 7分、生后 5minApgar评分≤ 7分 )引入Logistic回归模型进行多因素分析则仅有产程延长和生后 1minApgar评分≤ 7分为HIE的危险因素 ,OR分别为 6 5 80 ,110 0 98,95 %CI分别为 1 789～ 2 4 197,0 5 6 9～ 92 938。同时生后 1minApgar评分分别与HIE发病时间、病情严重程度比较差异有显著性 (P <0 0 1)。结论 :单因素分析所提示的危险因素是新生儿窒息的危险因素 ,也是HIE的相关因素 ,而多因素分析所提示的危险因素是HIE的危险因素 ,且与HIE发病时间及病情严重程度密切相关。避免新生儿窒息 ,防治HIE ,?
Objective: To study the risk factors of neonatal hypoxic-ischemic encephalopathy (HIE) and related factors to achieve the purpose of early prevention and early intervention. Methods: Totally 213 HIE patients were selected. At the same time, 68 non-HIE patients were randomly selected as the control group. Twenty-two risk factors were listed from 3 aspects: mother, fetus and childbirth. Univariate analysis and logistic regression analysis were performed using STATISTICA60 and Chinese medical encyclopedia statistical software. Results: Univariate analysis showed that there were 8 factors (pregnancy-induced hypertension, fetus head fetus delivery, prolonged labor, acute birth, meconium-stained amniotic fluid and umbilical cord abnormalities, Apgar score ≤ 7 points after birth After 5minApgar score ≤ 7 points) as a risk factor. Logistic regression was introduced into six factors (pregnancy-induced hypertension, fetal head suction, labor prolongation, prolonged labor, 1 min. Of Apgar score at 1 min after birth, and 5 min of Apgar score at birth) after univariate analysis were statistically significant In multivariate analysis, only the risk of HIE was prolonged with labor prolongation and 1 min after birth. The odds ratios for OR were 6 5 80, 110 0 98 and 95% CI 1 789 ~ 2 4 197 0 5 6 9 ~ 92 938. At 1 minute after birth, the Apgar score was significantly different from the onset time of HIE and the severity of illness (P <0.01). Conclusion: The risk factors suggested by univariate analysis are the risk factors of neonatal asphyxia and the related factors of HIE. The risk factors suggested by multivariate analysis are risk factors of HIE, and are closely related to the onset of HIE and the severity of the disease . Avoid neonatal asphyxia, prevent HIE,?