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目的探讨质子泵抑制剂对消化性溃疡出血的疗效。方法95例为我科1年来住院的消化性溃疡出血患者,均排除慢性肝病、血液病等影响凝血机制疾患者,随机分为A、B两组,A组为治疗组,48例,B组为对照组,47例,均给予质子泵抑制剂治疗,但不同的是A组给予质子泵抑制剂首次剂量80mg,并以8mg/h维持24～48h;B组给予质子泵抑制剂40mg,每日2次。结果A组显效30例,有效17例,无效1例,总有效率97.9%;B组显效18例,有效21例,无效8例,总有效率83%,两组对比P<0.05。结论质子泵抑制剂“80+8”剂量治疗消化性溃疡出血有显著疗效,未见明显不良反应。
Objective To investigate the effect of proton pump inhibitors on peptic ulcer bleeding. Methods One hundred and fifty-five patients with peptic ulcer hemorrhage hospitalized in our department for one year were excluded from the patients with chronic liver disease, hematological diseases and other factors affecting the coagulation mechanism. They were randomly divided into A and B groups. A group was treated group, 48 cases were B group For the control group, 47 cases were given proton pump inhibitor treatment, but the difference is that A group given proton pump inhibitor first dose 80mg, and 8mg / h maintained for 24-48h; B group proton pump inhibitor 40mg, each 2 times a day. Results In group A, 30 cases were markedly effective, 17 cases were effective, 1 case was ineffective, and the total effective rate was 97.9%. In group B, 18 cases were markedly effective, 21 cases were effective, 8 were ineffective and the total effective rate was 83%. Conclusion Proton pump inhibitor “80 +8” dose of peptic ulcer bleeding have a significant effect, no significant adverse reactions.