Giant prolactinomas in women

• 作 者: Delgrange E Raverot G Bex M Burman P Decoudier B Devuyst F Feldt-Rasmussen U Andersen M Maiter D
• 机 构: Service d'Endocrinologie,Centre Hospitalier Universitaire de Mont-Godinne,Universite Catholique de L
• 出 处: 中国神经肿瘤杂志
• 发表日期: 2013年04期
• 关键词: Giant women inclusion retrospective prolactin responding giant distinctive media

OBJECTIVE:To characterise distinctive clinical features of giant prolactinomas in women.DESIGN:A multicentre,retrospective case series and literature review.METHODS:We collected data from 15 female patients with a pituitary turnout larger than 4 cm and prolactin levels above 1000μg/l and identified 19 similar cases from the literature;a gender-based comparison of the frequency and age distribution was obtained from a literature review.RESULTS:The initial PubMed search using the term giant prolactinomas’identified 125 patients(13 women)responding to the inclusion criteria.The female:male ratio was 1:9.Another six female patients were found by extending the literature search,while our own series added 15 patients.The median age at diagnosis was 44 years in

OBJECTIVE: To characterize distinctive clinical features of giant prolactinomas in women. DESIGN: A multicentre, retrospective case series and literature review. METHODS: We collected data from 15 female patients with a pituitary turnout larger than 4 cm and prolactin levels above 1000 μg / l and identified 19 similar cases from the literature; a gender-based comparison of the frequency and age distribution was obtained from a literature review .RESULTS: The initial PubMed search using the term giant prolactinomas’ identified 125 patients (13 women) responding to the inclusion criteria The female: male ratio was 1: 9.Another six female were found by extending the literature search, while our own series added 15 patients.The median age at diagnosis was 44 years in