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目的比较苯磺酸氨氯地平片和硝苯地平控释片治疗原发性高血压病的疗效。方法选择初诊为高血压病且未经降压药物干预治疗的100例作为观察对象,随机分为研究组和对照组各50例。研究组给予左旋氨氯地平片治疗,对照组给予硝苯地平片治疗。观察2组临床疗效、24h血压变化情况及不良反应发生率。结果 2组治疗后血压均较治疗前降低,差异有统计学意义(P<0.05);2组治疗后收缩压和舒张压比较差异无统计学意义(P>0.05)。研究组总有效率为96.0%,对照组为92.0%,差异无统计学意义(P>0.05)。研究组不良反应发生率为16.0%,低于对照组的42.0%,差异有统计学意义(P<0.05)。结论左旋氨氯地平片和硝苯地平控释片两者均为安全有效的降压药物,但前者不良反应较少,临床耐受性良好。
Objective To compare the efficacy of amlodipine besylate tablets and nifedipine controlled release tablets in the treatment of essential hypertension. Methods A total of 100 patients with newly diagnosed hypertension without intervention of antihypertensive drugs were selected as observation subjects and randomly divided into study group (50 cases) and control group (50 cases). The study group was treated with levamlodipine and the control group with nifedipine. The clinical curative effect, the change of blood pressure in 24h and the incidence of adverse reactions were observed. Results The blood pressure of the two groups after treatment was lower than that before treatment, the difference was statistically significant (P <0.05). There was no significant difference in systolic pressure and diastolic pressure between the two groups after treatment (P> 0.05). The total effective rate was 96.0% in the study group and 92.0% in the control group, with no significant difference (P> 0.05). The incidence of adverse reactions in the study group was 16.0%, which was lower than that in the control group (42.0%), the difference was statistically significant (P <0.05). Conclusions Both L-amlodipine and nifedipine GITS are safe and effective antihypertensive drugs, but the former have fewer adverse reactions and good clinical tolerance.