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哮喘患者在不同刺激下容易引起支气管痉挛。气管插管可促使胆碱能神经节后纤维释放乙酰胆碱,通过迷走神经反射导致支气管痉挛。最近,作者在动物模型中证实:七氟醚与氟烷均能有效地防止乙酰甲胆碱引起的肺阻力增加。然而,七氟醚用于哮喘儿童的安全性尚无报道。 本研究的目的是通过测量哮喘和无哮喘儿童七氟醚麻醉诱导时气管插管前后肺功能的变化,观察七氟醚对插管前后引起气道阻力的影响。
Patients with asthma in different stimuli easily lead to bronchospasm. Intubation can promote the release of acetylcholine in the cholinergic ganglion fibers and bronchospasm via vagal reflex. Recently, the authors confirmed in animal models that both sevoflurane and halothane effectively prevent methacholine-induced increases in lung resistance. However, the safety of sevoflurane for asthmatic children has not been reported. The aim of this study was to investigate the effects of sevoflurane on airway resistance before and after intubation by measuring changes in lung function before and after endotracheal intubation induced by sevoflurane anesthesia in asthmatic and asthmatic children.