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垂体促性腺激素(促卵泡成熟激素FSH和黄体生成素LH)调节卵巢机能,刺激甾体激素的分泌,甾体激素作用于下丘脑-垂体系统,构成调节促性腺激素分泌的反馈机制的重要成分。近来的资料表明,卵巢甾体也可直接作用于有关卵巢细胞,调节卵巢对促性腺激素的反应。本文综述这些甾体在卵巢内局部作用的部位和机理,及其在调节卵巢甾体生物合成方面与垂体促性腺激素的相互作用。一、雌激素生物合成的调节 (一)作为底物的雄激素在促性腺激素引起的雌激素生物合成中的作用:雄激素,即雄烯二酮和/或睾酮是雌激素生物合成所必需的中间物质。LH刺激雌激素生成的能力
Pituitary gonadotropins (follicle-stimulating hormone FSH and luteinizing hormone LH) regulate ovarian function and stimulate the secretion of steroid hormones that act on the hypothalamus-pituitary system and constitute an important component of the feedback mechanism regulating gonadotropin secretion . Recent data suggest that ovarian steroids may also act directly on ovarian cells and regulate ovarian responses to gonadotropins. This article reviews the site and mechanism of the local role of these steroids in the ovary and their interactions with pituitary gonadotropins in regulating ovarian steroid biosynthesis. The regulation of estrogen biosynthesis (a) The role of androgens as substrates in gonadotropin-induced estrogen biosynthesis: Androgens, ie, androstenedione and / or testosterone, are required for estrogen biosynthesis Of the intermediate substance. LH stimulates estrogen production