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用抗菌药物治疗流行性脑脊髓膜炎(简称流脑)的效果较好,除慢性脑膜炎球菌败血症外,很少出现再发。近十余年来,国外对脑膜炎球菌感染的发病与免疫缺陷(以先天性免疫缺陷为主)的关系进行了一些观察和研究,现将有关情况综合如下:一、缺乏补体急性流脑多发生于缺乏血清杀菌性抗体(IgG)者。曾观察到有5~10%的流脑患者血清中缺乏补体。群特异的脑膜炎球菌抗体或补体单独存在,只能刺激一小部分中性多核粒细胞吞噬及消灭脑膜炎球菌,而只有当两者都具备时,才能最大限度地刺激中性多
With antimicrobial drugs for the treatment of epidemic meningococcal meningitis (referred to as meningitis) better, with the exception of chronic meningococcal sepsis, rarely recurrence. In the recent ten years, some foreign observations and studies on the relationship between the incidence of meningococcal infection and immunodeficiency (mainly of congenital immunodeficiency) are as follows: First, the lack of complement acute meningitis Occurs in the lack of serum bactericidal antibodies (IgG). It has been observed that 5 to 10% of meningitis patients lack serum complement. Group-specific meningococcal antibodies or complement alone exist and can only stimulate a small fraction of neutral multinucleated granulocytes to phagocytose and eliminate meningococci, but only when both are present can maximally stimulate neutrality