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目的探讨高血压患者血清endocan水平与冠心病发病的关系。方法高血压患者165例,依据是否合并冠心病分为冠心病组85例和无冠心病组80例,测定2组血清endocan水平,采用logistic回归分析血清endocan水平与高血压患者发生冠心病的关系。结果冠心病组血清endocan水平[1.52(0.79,1.90)ng/L]高于无冠心病组[0.86(0.44,1.23)ng/L](P<0.01);logistic回归分析结果显示,血清endocan水平与高血压患者发生冠心病呈正相关(OR=1.24,95%CI:1.09~1.63,P=0.001)。结论血清endocan水平是高血压患者发生冠心病的独立危险因子。
Objective To investigate the relationship between serum endocan levels and the incidence of coronary heart disease in patients with hypertension. Methods One hundred and sixty-five patients with hypertension were divided into coronary heart disease group (85 cases) and coronary heart disease group (80 cases). The serum endocan levels were measured in two groups. Logistic regression analysis was used to analyze the relationship between endocan levels and coronary heart disease in hypertensive patients . Results The level of endocan in patients with coronary heart disease was significantly higher than that in patients without coronary heart disease [1.52 (0.79, 1.90) ng / L] [0.86 (0.44,1.23) ng / L] (P <0.01). Logistic regression analysis showed that serum endocan level Coronary heart disease was positively correlated with hypertension (OR = 1.24, 95% CI: 1.09-1.63, P = 0.001). Conclusions Serum endocan level is an independent risk factor for CHD in hypertensive patients.