甲基强的松龙冲击疗法治疗皮肌炎

• 作 者: 沈宁江
• 机 构: 新疆医学院附一院,
• 出 处: 皮肤病防治
• 发表日期: 1984年Z2期
• 关键词: 皮肌炎 冲击疗法 氨甲喋呤 弥漫性炎症 皮肤炎 乳酸脱氢酶 常用量 醛缩酶 免疫性疾病 肌酸磷酸激酶

皮肤炎是一种皮肤和肌肉的弥漫性炎症性疾病,血清内肌酶[如肌酸磷酸激酶(CPK)、乳酸脱氢酶(LDH)、醛缩酶]和多种转移酶升高。大多数皮肌炎患者经常用量皮质类固醇激素治疗后,可迅速收效,但约20％左右的患者无满意疗效,且全身情况迅速恶化。有人提出对这些病人可用氨甲喋呤或其它免疫抑制剂治疗。

Dermatitis is a diffuse inflammatory disease of the skin and muscles. Serum creatine enzymes [such as creatine phosphokinase (CPK), lactate dehydrogenase (LDH), aldolase] and various transferases are elevated. Most patients with dermatomyositis often receive high doses of corticosteroids, which can be rapidly effective, but about 20% of patients with no satisfactory effect, and the general condition deteriorated rapidly. It has been suggested that these patients may be treated with methotrexate or other immunosuppressive agents.