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山莨菪碱是莨菪类植物中提取分离的新药,过去结果表明,药物能降低磷脂膜的有序度,诱发磷脂酰乙醇胺及一些带电荷磷脂形成非脂双层的H_(11)结构。此外,还对大鼠突触膜上多种ATP酶产生抑制作用。生理实验业已表明,山莨菪碱作用于神经系统主要抑制神经递质乙酰胆碱的释放及与其受体的结合,而乙酰胆碱的释放主要是由神经元内Ca~(2+)来调节的,为此,本文以注射法制备的单层脂质体为模型,研究山莨菪碱对中性磷脂二棕榈酰磷
Anisodamine is a new drug extracted and extracted from the plants of the genus Androsa. Past results show that the drug can reduce the orderliness of the phospholipid membrane and induce the H 11 structure of phosphatidylethanolamine and some charged lipids to form non-lipid bilayers. In addition, a variety of ATPase in rat synaptic membrane inhibition. Physiological experiments have shown that anisodamine acts on the nervous system primarily to inhibit the release of the neurotransmitter acetylcholine and its binding to its receptor, whereas the release of acetylcholine is mainly regulated by Ca 2+ in neurons. To this end, In this paper, single-layer liposome prepared by injection method for the model study of anisodamine on the neutral phospholipid dipalmitoylphosphate