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Dendritic cells(DCs) are recognized as the most potent antigen-presenting cells(APCs) with the ability tostimulate naive resting T cells and initiate primary immune responses.DCs are poised to capture antigen(Ag),migrate to draining lymphoid organs,and,after a process of maturation,select Ag-specific lymphocytes towhich they present the processed Ag,thereby inducing immune responses.Numerous studies indicated thatimmunotherapies utilizing DC-presenting tumor-associated antigens can safely be administered to cancerpatients and induce significant immunologic and clinical responses.Moreover,it has been demonstrated thatDCs are related to clinical stage,invasion,metastasis and prognosis of gastric cancer.DC-based tumor vaccinesbecome a new effective immunoadjuvant therapy for gastric cancer.Cellular & Molecular Immunology.2004;1(5):351-356.
Dendritic cells (DCs) are recognized as the most potent antigen-presenting cells (APCs) with the ability tostimulate naive resting T cells and primary immune responses. DCs are poised to capture antigen (Ag), migrate to draining lymphoid organs, and, after a process of maturation, select Ag-specific lymphocytes towhich they present the processed Ag, thereby inducing immune responses. Numerous studies indicated thatimmunotherapies utilizing DC-presenting tumor-associated antigens can safely be administered to cancer patients and induce significant immunologic and clinical responses. Moreover , it has been demonstrated that DCCs are related to clinical stages, invasion, metastasis and prognosis of gastric cancer. DC-based tumor vaccines benefit a new effective immunoadjuvant therapy for gastric cancer. Cellular & Molecular Immunology. 2004; 1 (5): 351-356 .