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目的：通过临床机械性创伤患者血清的分析，探讨血清异常蛋白与创伤患者预后的关系．方法：收集了２６例创伤患者血清，按创伤严重度评分将患者分为轻度（ＩＳＳ＜１６），中度（ＩＳＳ１６～２５），重度（ＩＳＳ≥２５）三组；分别检测了其血清对正常人外周血单个核细胞（ＰＢＭＣ）转化和ＩＬ－２产生的影响；观测了血清抑制性、创伤严重度评分与患者预后的关系．结果：随着创伤严重度增加，血清的免疫抑制性亦明显增强，ＰＢＭＣ转化降低；ＩＬ－２产生减少；有１０例患者血清可检测出明显的异常蛋白（分子量约为９０００），创伤愈重，异常蛋白出现频率亦愈高，检出异常蛋白者ＩＳＳ明显高于未检出异常蛋白患者（２３／１４．６）．结论：机械性创伤患者血清中可检出具有免疫抑制性的异常蛋白，该异常蛋白可能是创伤后免疫抑制的主要原因之一，异常蛋白的出现往往预示着创伤患者的不良预后
Objective: To investigate the relationship between serum abnormal protein and the prognosis of trauma patients through the analysis of the serum of clinical trauma patients. Methods: Twenty-six trauma patients were collected and divided into mild (ISS <16), moderate (ISS 16-25), and severe (ISS> 25) Normal human peripheral blood mononuclear cells (PBMC) transformation and IL-2 production; observed serum inhibition, the severity of trauma score and the relationship between the prognosis of patients. Results: With the increase of the severity of trauma, the immunosuppression of serum was also significantly enhanced, the PBMC transformation was decreased and the production of IL-2 was decreased. In 10 cases, the serum was detected with abnormal protein (molecular weight about 9,000) , The higher the frequency of abnormal protein, the detection of abnormal protein ISS was significantly higher than those who did not detect abnormal protein (23 / 14.6). Conclusion: Abnormal protein with immuno-suppressive activity can be detected in sera of patients with traumatic trauma. This aberrant protein may be one of the major causes of post-traumatic immunosuppression. Abnormal protein often indicates the poor prognosis of trauma patients