论文部分内容阅读
目的：研究氟康唑对重症监护室（ Ｉ Ｃ Ｕ） 病人尿路真菌感染的预防作用。方法：留置导尿的颅脑外伤和脑血管意外病人１３０ 例分为３ 组：对照组（４２例） ，不给抗真菌药物；氟康唑５０ ｍ ｇ 组（４９ 例） ，用氟康唑５０ ｍｇ ，ｑｄ ， 始于置管后（２ ．８ ±１ ．２） ｄ ； 氟康唑１００ ｍｇ 组（３９ 例） ，用１００ ｍ ｇ ，ｑｄ ， 始于置管后（２ ．７ ±１ ．３） ｄ 。氟康唑均由胃管注入或口服。每周作１ 次尿真菌培养等检查。结果：对照组ｗ ｋ １ ，２ ，３ 尿路真菌感染率分别为６２ ％ ，８３ ％ 和８５ ％ ；氟康唑５０ ｍｇ 组分别为４３ ％ ，３５ ％ 和１４ ％ 。１００ ｍｇ 组分别为３６ ％ ，２９ ％ 和２２ ％ 。２ 用药组ｗｋ ２ ， ３ 的感染率显著降低（ Ｐ＜ ０ ．０１） 。结论：氟康唑（５０ ｍ ｇ 或１００ ｍｇ ，ｑｄ） 能安全有效地预防 Ｉ Ｃ Ｕ 病人尿路真菌感染。
Objective: To study the preventive effect of fluconazole on urinary tract fungal infection in intensive care unit (ICU) patients. Methods: One hundred and thirteen patients with traumatic brain injury and cerebrovascular accident who had catheterization were divided into three groups: control group (n = 42) without antifungal drugs; fluconazole 50 m g group (n = 49) 50 mg qd, beginning after catheterization (2.8 ± 1.2 days); fluconazole 100 mg group (39 cases), with 100 m g, qd, beginning after catheterization (2.7 ± 1 .3) d. Fluconazole is administered by the stomach tube or orally. Once a week for urinary fungal culture and other tests. Results: The urinary tract fungal infection rates wk 1, 2 and 3 in the control group were 62%, 83% and 85%, respectively, and those in the fluconazole 50 mg group were 43%, 35% and 14%, respectively. The 100 mg group was 36%, 29% and 22%, respectively. 2 infection wk 2, 3 infection rate was significantly lower (P <0 .01). CONCLUSION: Fluconazole (50 m g or 100 mg, qd) is safe and effective in preventing urinary tract fungal infections in patients with I C U.