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两种百日咳无细胞菌苗在瑞典进行的大规模现场试验未能证明有足够的效力,也不可能于近期内在美国批准为候选菌苗。与此同时,对受试者和安慰剂对照者发病的追踪研究确能证实两种菌苗对百日咳有一定防御作用。通过对这一议论纷纷的试验结果的初步分析,得到一些重要发现,最近几周在美国国立卫生研究院作了报告。在此之前在斯德哥尔摩进行过审议,不久将在Lancet杂志上发表初步报告。此次现场试验是一项国际通力合作,参加单位有:斯德哥尔摩的国立细菌学研究室、
Large-scale field trials of two B. pertussis cell-free bacterins in Sweden failed to demonstrate sufficient efficacy and could not be approved as potential vaccine in the United States in the near future. In the meantime, follow-up studies of the incidence of subjects and placebo confirmed that both vaccines had a defensive effect on whooping cough. Some important findings have been obtained through a preliminary analysis of the results of this controversial trial, which was reported at the NIH in recent weeks. Prior to this consideration in Stockholm, Lancet will soon publish a preliminary report. The field test is an international cooperation, the participating units are: Stockholm National Bacteriology Laboratory,