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血小板衍生生长因子(PDGF)是由骨髓巨核细胞合成的具有高度催化活性的糖蛋白,贮存于血小板a-颗粒中,在血液凝固过程中释放人血清。PDGF是结缔组织生长的局部调节剂,其病理作用为加速成纤维母细胞的增殖和刺激网状纤维或胶原纤维的产生。可能成为骨髓纤维化的主要病因,为此,作者观察了8例初发骨髓增殖性疾病患者的全血清(WBS)和无血小板血浆(PPP)之间PDGF促丝裂活性的差异,并与10例正常人进行比较。其方法如下,根据PDGF能够促进Go期3T3成纤维母细胞株进入S期,在体外生长的能力,体外培
Platelet-derived growth factor (PDGF) is a highly catalytically active glycoprotein synthesized by bone marrow megakaryocytes stored in platelet a-particles, releasing human serum during blood clotting. PDGF is a local regulator of connective tissue growth whose pathological effects are to accelerate the proliferation of fibroblasts and stimulate the production of reticular or collagen fibers. May be the major cause of myelofibrosis. To this end, the authors observed differences in PDGF mitogenic activity between whole blood serum (WBS) and platelet-free plasma (PPP) in 8 patients with primary myeloproliferative disease and compared with 10 Cases of normal people to compare. The method is as follows, according to PDGF can promote Go phase 3T3 fibroblast cell line into the S phase, the ability to grow in vitro, in vitro training