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10例对利尿剂和洋地黄无效的Ⅲ或Ⅳ级充血性心衰病人,研究前停用一切扩血管剂至少48小时,停用利尿剂至少24小时。所有病人待血流动力学稳定后在3分钟内静注尼索地平(NIS)1.5μg/kg,若平均动脉压和/或左室充盈压的降低小于给药前的25％,且收缩压大于85mmHg,则再静注NIS3.0μg/kg;若仍未达到上述标准,则再静注NIS6.0μg/kg。研究期间,定时测有关参数。结果:10例病人均给予首剂NIS,9例给予第2剂,4例给予第3剂。前两剂平均间期为202(150～253)分钟,后两剂平均间期为183(174～202)分钟。在首剂后,平均动
Ten patients with grade III or IV congestive heart failure who were refractory to diuretics and digitalis were discontinued of all vasodilators for at least 48 hours prior to the study and diuretics discontinued for at least 24 hours. All patients received nisoldipine (NIS) 1.5 μg / kg intravenously within 3 minutes after haemodynamic stabilization. If the mean arterial pressure and / or LV filling pressure decreased less than 25% before administration, and systolic pressure Greater than 85mmHg, then intravenous NIS3.0μg / kg; if still not meet the above criteria, then intravenous injection of NIS6.0μg / kg. During the study, the relevant parameters are measured regularly. Results: The first dose of NIS was given in 10 patients, the second dose in 9 patients and the third dose in 4 patients. The first two agents had an average interval of 202 (150-253) minutes, with an average of 183 (174-202) minutes after the last two doses. After the first dose, the average move