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目的检测原发性肝癌患者血清中可溶性单纯疱疹病毒侵入介体(sHVEM)的水平并探讨其临床意义。方法应用夹心ELISA法检测41例原发性肝癌患者和48例健康体检者血清中sHVEM水平。结果原发性肝癌患者血清sHVEM水平为(81.2±22.8)μg/L,正常人血清sHVEM为(39.9±22.3)μg/L,两者比较差异有统计学意义(P<0.05),且原发性肝癌患者血清sHVEM与甲胎蛋白(AFP)呈正相关(r=0.513,P<0.05);Ⅲ/Ⅳ期原发性肝癌患者血清sHVEM水平为(102.1±55.8)μg/L,显著高于Ⅰ/Ⅱ期患者(58.5±30.1)μg/L,差异有统计学意义(P<0.05);术后原发性肝癌患者血清sHVEM水平为(74.8±27.4)μg/L,显著低于术前(98.7±38.5)μg/L,差异有统计学意义(P<0.05)。结论原发性肝癌患者血清中高水平的sHVEM与临床分期、治疗情况及其他肿瘤标志物相关,提示sHVEM可能在原发性肝癌的发生发展中起重要作用,检测sHVEM对原发性肝癌的诊断及疗效评估有一定的意义。
Objective To detect the level of soluble herpes simplex virus invade mediator (sHVEM) in patients with primary liver cancer and to explore its clinical significance. Methods Sandwich ELISA was used to detect serum levels of sHVEM in 41 patients with primary liver cancer and 48 healthy controls. Results The serum levels of sHVEM in patients with primary liver cancer were (81.2 ± 22.8) μg / L and those in normal persons were (39.9 ± 22.3) μg / L, respectively, with statistical significance (P <0.05) Serum levels of sHVEM and AFP in patients with HCC were positively correlated (r = 0.513, P <0.05); serum levels of sHVEM in patients with HCC were (102.1 ± 55.8) μg / L, significantly higher than those in patients with Ⅰ / (58.5 ± 30.1) μg / L, the difference was statistically significant (P <0.05). The serum level of sHVEM in patients with primary liver cancer was (74.8 ± 27.4) μg / L, which was significantly lower than that of preoperative 98.7 ± 38.5) μg / L, the difference was statistically significant (P <0.05). Conclusion The high serum levels of sHVEM in patients with primary liver cancer correlate with clinical stage, treatment and other tumor markers, suggesting that sHVEM may play an important role in the development of primary liver cancer. The detection of sHVEM in primary liver cancer and Efficacy evaluation has some significance.