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长久以来,苯酚类试剂被作为一种保存剂广泛地出现于各种胰岛素制剂中。但其功效并没有从理论上得以阐明。1958年,Schlichkrull在不同于传统的三方二锌及三方四锌胰岛素晶体生长体系中得到单斜胰岛素晶体,其中最大的差别是体系中含有浓度为1.0％的苯酚(phenol)。1964年,Kreyenbuhl和Rosenberg也报道了苯酚和间甲基苯酚(m-cresol)是制备长效胰岛素药物胰岛素-鱼精蛋白(NPH)复合物的必需条件。至此,人们开始注意到
Phenolic agents have long been widely used as a preservative in various insulin preparations. But its efficacy has not been theoretically elucidated. In 1958, Schlichkrull obtained monoclinic insulin crystals in a system different from that of the conventional tribasic zinc and tribasic insulin growth system, the biggest difference being that the system contained phenol in a concentration of 1.0%. In 1964, Kreyenbuhl and Rosenberg also reported that phenol and m-cresol are required for the preparation of the long-acting insulin drug, the insulin-protamine (NPH) complex. At this point, people began to notice