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有关持续抗-HCV阳性而无肝病症状和体征的HCV感染者的临床治疗尚有争议。本文作者通过对15例ALT正常的无症状携带者的肝标本活检,以确定肝病的流行率及抗-HCV和HCV RNA阳性与组织学变化的关系。 对所有研究对象进行体检、肝脏超声检查、CT检查及常规肝功能试验。经皮肝穿刺获得肝标本,经过福尔马林固定,石蜡包埋肝切片,用苏木精-伊红染色后,按国际分类法作组织学诊断。 15例研究对象均无肝病症状和体征,ALT正常至少3年;用第二代酶联免疫吸
The clinical management of HCV-infected individuals with persistent anti-HCV positive disease-free symptoms and signs of liver disease remains controversial. The authors examined the prevalence of liver disease and the relationship between anti-HCV and HCV RNA positive and histological changes in 15 liver samples from asymptomatic ALT carriers. All subjects were examined by physical examination, liver ultrasound examination, CT examination and routine liver function tests. Percutaneous liver biopsy specimens obtained liver, fixed in formalin, paraffin-embedded liver sections, stained with hematoxylin-eosin, according to international classification for histological diagnosis. All 15 subjects had no symptoms and signs of liver disease, ALT normal for at least 3 years; with second-generation enzyme-linked immunosorbent