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目的:探讨反复呼吸道感染(RRI)患儿与树突状细胞活性密切相关的细胞免疫及体液免疫功能指标的变化及其临床意义。方法:分别检测53例反复呼吸道感染患儿外周血CD3、CD4、CD4/CD8淋巴细胞亚群及免疫球蛋白IgG、IgA、IgM的含量变化,并和具可比性的36例健康儿进行对照研究。结果:RRI患儿CD3、CD4、CD4/CD8与对照组比均明显下降,差异有统计学意义(P<0.05),CD8无明显变化(P>0.05);免疫球蛋白IgG、IgA含量显著性下降,差异有统计学意义(P<0.05),IgM无明显变化(P>0.05)。结论:RRI患儿存在免疫功能失调,细胞免疫和体液免疫功能均有不同程度的下降,并可能与患儿的发病、病情转归、预后等有关,这些指标的变化可作为评价疗效的参考指标。进一步分析小儿RRI的树突状细胞活性变化可作为更全面研究小儿RRI的另一个有价值的角度。
Objective: To investigate the changes of cellular immunity and humoral immune function in children with recurrent respiratory tract infection (RRI) and their dendritic cell activity and their clinical significance. Methods: The levels of CD3, CD4, CD4 / CD8 lymphocytes and IgG, IgA and IgM in peripheral blood of 53 children with recurrent respiratory tract infection were detected and compared with 36 healthy children . Results: The ratio of CD3, CD4 and CD4 / CD8 in RRI patients was significantly lower than that in control group (P <0.05), but there was no significant change in CD8 (P> 0.05). The immunoglobulin IgG and IgA contents were significantly higher (P <0.05), but there was no significant change in IgM (P> 0.05). CONCLUSIONS: There are immune dysfunction, cellular immunity and humoral immune function in children with RRI have different degrees of decline, and may be related to the incidence of children, prognosis, prognosis, etc. These changes can be used as a reference index to evaluate the efficacy . Further analysis of changes in dendritic cell activity in pediatric RRIs may serve as another valuable perspective for a more comprehensive study of pediatric RRIs.