西安市城市居民食管癌遗传度的调查

• 作 者: 韩成龙 李良寿 万志恒
• 机 构: 第四军医大学流行病学教研室,第四军医大学流行病学教研室,第四军医大学流行病学教研室
• 出 处: 第四军医大学学报
• 发表日期: 1986年02期
• 关键词: 一级亲属 西安市 食管癌 多基因遗传 肿瘤病 遗传度 城市居民 食管癌发病 致癌物 预防措施

对西安市115例食管癌患者的配对调查发现,患者一级亲属1207人,其中有30人发生食管癌;而与患者性别、民族相同,年龄相差5岁以内,相应非肿瘤病人对照者1012人的一级亲属中,仅9人发生食管癌。计算得食管癌的遗传度为40.6％。这提示遗传因素可能在食管癌的发病中起一定作用,在有食管癌家族史的人群中,把防止致癌物(如吸烟等)的引入作为预防措施是有意义的。

A paired survey of 115 patients with esophageal cancer in Xi’an found that there were 1207 first-degree relatives of the patients, of whom 30 had esophageal cancer; the patients were of the same gender and nationality, the age difference was less than 5 years, and the corresponding non-cancer patient control group was 1012 people. Of the first-degree relatives, only 9 people developed esophageal cancer. The heritability of esophageal cancer was calculated to be 40.6%. This suggests that genetic factors may play a role in the pathogenesis of esophageal cancer. In populations with a family history of esophageal cancer, it makes sense to use prevention of carcinogens (such as smoking) as a preventive measure.