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79例具有反酸、烧心、胸骨后疼痛症状的患者 ,内镜检查食管炎 40例 ,内镜阴性 39例 ,用Biostar 2 4hpH监测系统记录两组患者生理状态下 2 4h食管pH变化 ,以了解内镜阴性与内镜阳性反流症状患者之间反流状况的异同及与临床症状的关系。结果发现 ,DeMeester Johnson记分系统各项指标食管炎组明显高于内镜阴性组 ,其中总积分分别为 (85 85± 15 0 9)和 (2 6 2 0± 5 76 ) (P <0 0 0 1) ;症状次数分别为 (2 0 36± 5 2 5 )和 (2 2 33± 4 76 ) (P >0 0 5 ) ;反流次数分别为 (2 49 2 2± 2 9 5 9)和 (79 18± 15 37) (P <0 0 0 0 1)。症状特异性分别为 73 0 7%和 42 2 3% (P <0 0 0 3) ;症状敏感性分别为 8 0 2 %和 17 19% (P <0 0 0 1)。提示食管炎患者具有明显的胃食管反流 ,其反流症状的发生与酸反流密切相关 ;内镜阴性患者部分反流症状的发生不伴有酸反流的存在。
79 cases of patients with acid reflux, heartburn and sternum pain, 40 cases of endoscopic esophagitis and 39 cases of endoscopic negative. Biostar 2 4hpH monitoring system was used to record the change of esophageal pH at 24 hours in both groups Similarities and Differences of Reflux Status between Patients with Endoscopic Negative and Endoscopic Positive Reflux Symptoms and Their Relationship with Clinical Symptoms. The results showed that the indexes of DeMeester Johnson scoring system were significantly higher in esophagitis group than in endoscopy negative group, with the total score of (85 85 ± 15 0 9) and (2620 ± 5 76) 1); the number of symptoms were (2 0 36 ± 5 2 5) and (2 2 33 ± 4 76) respectively (P 0 05); the number of reflux was (2 49 2 2 ± 2 9 5 9) and (79 18 ± 15 37) (P <0 0 0 0 1). The symptom specificity was 73 0 7% and 42 2 3% respectively (P 0 0 0 3). The symptom sensitivity was 82.02% and 17 19% respectively (P 0 01). The results suggest that patients with esophagitis have obvious gastroesophageal reflux and the occurrence of reflux symptoms is closely related to acid reflux. Partial reflux symptoms in patients with endoscopic negative are not associated with acid reflux.