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目的了解急性冠脉综合征(ACS)患者血浆二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)水平及其与载脂蛋白B100(ApoB100)/载脂蛋白A1(ApoA1)比值关系,为ACS的预防控制提供参考依据。方法于2011年6月—2016年6月整群抽取在黑龙江省牡丹江医学院第二附属医院和牡丹江红旗医院行冠脉造影检查者860人,将其中确诊的610例ACS患者和250名健康者分别作为病例组和对照组进行实验室检测,比较2组人群的血浆EPA、DHA及血清ApoB100、ApoA1和ApoB100/ApoA1比值水平,分析ACS患者血浆EPA、DHA水平及其与ApoB100/ApoA1比值关系。结果病例组患者血浆EPA、DHA和血清ApoA1分别为(3.02±0.25)%、(2.42±0.24)%和(1.21±0.25)g/L,均低于对照组健康者的(3.51±0.32)%、(2.88±0.29)%和(1.42±0.32)g/L,差异均有统计学意义(均P<0.001);病例组患者血清ApoB100和ApoB100/ApoA1比值分别为(1.05±0.23)g/L和(0.87±0.22),均高于对照组健康者的(0.73±0.12)g/L和(0.51±0.16),差异均有统计学意义(均P<0.001);Spearman相关分析结果显示,ACS患者血浆EPA、DHA水平与ApoB100/ApoA1比值均呈负相关(r=-0.762、-0.783,均P<0.05)。
Objective To investigate the plasma level of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in patients with acute coronary syndrome (ACS) and its correlation with levels of apolipoprotein B100 (ApoB100) / apolipoprotein A1 ) Ratio, provide a reference for the prevention and control of ACS. Methods From June 2011 to June 2016, 860 coronary angiography examinations were performed in the Second Affiliated Hospital of Mudanjiang Medical College and Mudanjiang Hongqi Hospital in Heilongjiang Province. One hundred and sixty ACS patients and 250 healthy subjects The levels of plasma EPA, DHA, serum ApoB100, ApoA1 and ApoB100 / ApoA1 in two groups were compared. The levels of plasma EPA and DHA and the ratio of ApoB100 / ApoA1 in ACS patients were also analyzed. Results The plasma levels of EPA, DHA and serum ApoA1 were (3.02 ± 0.25)%, (2.42 ± 0.24)% and (1.21 ± 0.25) g / L in the case group, which were all lower than those in the control group (3.51 ± 0.32)% , (2.88 ± 0.29)% and (1.42 ± 0.32) g / L, respectively (all P <0.001). The ratios of serum ApoB100 to ApoB100 / ApoA1 were (1.05 ± 0.23) g / L (0.73 ± 0.12) g / L and (0.51 ± 0.16), respectively (all P <0.001). The results of Spearman correlation analysis showed that ACS Plasma EPA, DHA levels were negatively correlated with ApoB100 / ApoA1 ratio (r = -0.762, -0.783, all P <0.05).