Itraconazole维持治疗艾滋病患者的隐球性脑膜炎

• 作 者: 张全贵
• 出 处: 国外医药.合成药.生化药.制剂分册
• 发表日期: 1989年02期
• 关键词: 艾滋病 球性 脑膜炎 隐球菌性脑膜炎 Itraconazole 氟胞嘧啶 两性霉素 人免疫缺陷病毒 伊曲康唑 机会感染

隐球性脑膜炎是艾滋病患者的一种致命性机会感染,所以在选择性联合应用两性霉素B与氟胞嘧啶后必须给予维持治疗。作者使用伊曲康唑(itraconazole),以防止艾滋病患者的隐球菌性脑膜炎。研究对象为5例抗人免疫缺陷病毒抗体阳性的患者。所有患者均从脑脊液中培养中分离出隐球菌性新型细球菌。每例均接受诱导治疗(每日静注两性霉素B 0.3mg/kg;每日口服氟胞嘧啶150mg/kg)6～8周。4例维持治疗口服伊曲康唑100mg,每日2次;

Cryptococcal meningitis is a fatal opportunistic infection in AIDS patients, so maintenance therapy must be given after the selective combination of amphotericin B and flucytosine. The authors used itraconazole to prevent cryptococcal meningitis in AIDS patients. The subjects were 5 patients with positive anti-human immunodeficiency virus antibody. All patients were isolated from the culture of cerebrospinal fluid Cryptococcus neoformans. Each case received induction therapy (daily intravenous amphotericin B 0.3mg / kg; daily oral flucytosine 150mg / kg) 6 to 8 weeks. 4 cases of maintenance therapy oral itraconazole 100mg, 2 times a day;