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目的:探讨丙种球蛋白治疗小儿川崎病疗效。方法:将2010年1月-2016年12月我院收治的36例小儿川崎病患者随机分为对照组和研究组,前者采用丙种球蛋白1g/kg/d,后者采用丙种球蛋白2g/kg/d,并均辅以阿司匹林治疗,比较两组患儿临床症状消失时间。结果:研究组患儿在退热、粘膜充血、淋巴结肿大和手足肿胀症状消失时间短于对照组,但无统计学差异(P>0.05)。研究组和对照组治疗总有效率分别为94.4%和100.0%,后者高于前者,但无统计学差异(P>0.05)。结论:给予大剂量的丙种球蛋白治疗小儿川崎病可有效缩短患儿临床症状消失时间,促进患儿疾病康复。
Objective: To investigate the therapeutic effect of gamma globulin on children with Kawasaki disease. Methods: Thirty-six children with Kawasaki disease admitted to our hospital from January 2010 to December 2016 were randomly divided into control group and study group. The former received gamma globulin 1g / kg / d and the latter received gamma globulin 2g / kg / d, both supplemented by aspirin treatment, the clinical symptoms disappeared in both groups. Results: The disappearance time of fever, mucosal hyperemia, lymph node enlargement and hand-foot swelling in study group was shorter than that in control group, but there was no significant difference (P> 0.05). The total effective rates of the study group and the control group were 94.4% and 100.0% respectively, which were higher than the former, but there was no significant difference (P> 0.05). Conclusion: The administration of large doses of gamma globulin in children with Kawasaki disease can effectively shorten the disappearance of clinical symptoms and promote the rehabilitation of children.