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目的:探讨新生儿持续性肺动脉高压(PPHN)应用硫酸镁与西地那非联合治疗的效果及安全性。方法:本文收集我院2015年7月-2016年9月期间收治的PPHN患儿84例作对比研究,以随机抽签的方式,将患者分为对照组(n=42例)和观察组(n=42例),两组均应用硫酸镁治疗,后者加用西地那非,通过对比分析的方式,探讨硫酸镁、西地那非联合治疗方案的疗效。结果:干预前,两组SPAP、PaCO_2、PaO_2对比,无明显差异(p>0.05),干预后,两组PaCO_2、SPAP均低于干预前(p<0.05),PaO_2高于干预前(p<0.05),组间干预后对比,观察组3项指标改善情况显著优于对照组(p<0.05);观察组不良反应发生率明显低于对照组(p<0.05)。结论:临床上针对PPHN患儿选取硫酸镁、西地那非联合治疗方案,可提升改善患儿肺动脉压效果,疗效显著。
Objective: To investigate the effect and safety of combination therapy with magnesium sulfate and sildenafil in neonatal persistent pulmonary hypertension (PPHN). METHODS: This study collected 84 children with PPHN who were treated in our hospital from July 2015 to September 2016. The randomized patients were divided into control group (n = 42) and observation group (n = 42 cases), both groups were treated with magnesium sulfate, the latter plus sildenafil, through the comparative analysis of the way to explore the efficacy of magnesium sulfate, sildenafil combined treatment. Results: Before intervention, there was no significant difference between the two groups (P> 0.05). After treatment, PaCO_2 and SPAP in both groups were significantly lower than those before intervention (p <0.05) 0.05). After intervention, the improvement of three indexes in the observation group was significantly better than that in the control group (p <0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (p <0.05). Conclusion: The clinical treatment of PPHN in children with magnesium sulfate, sildenafil combination therapy can improve the effect of pulmonary hypertension in children with significant effect.