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目的探讨力尔凡膀胱灌注预防浅表性膀胱尿路上皮癌术后复发的临床效果。方法对152例浅表性膀胱尿路上皮癌术后患者,随机分成2组。试验组:力尔凡+顺铂+放疗;对照组:单纯顺铂+放疗。对其复发率、复发间隔时间进行组间比较,对T细胞亚群和白细胞总数进行治疗前后的对比观察。结果试验组与对照组的复发率与复发间隔时间比较差异均有统计学意义(P均<0.05)。试验组治疗前后NK细胞、CD4/CD8计数比较差异均有统计学意义(P均<0.05),治疗后明显高于治疗前;对照组治疗前后白细胞总数比较差异有统计学意义(P<0.05),治疗后明显低于治疗前。结论力尔凡不但可以杀灭肿瘤细胞,而且有免疫复苏作用,在体内与其他免疫因子和化疗药物起协同作用,在膀胱尿路上皮癌的综合治疗中,不失为一种化疗配伍的安全、有效的药物选择。
Objective To investigate the clinical effect of li Er Fan bladder irrigation to prevent postoperative recurrence of superficial bladder urothelial carcinoma. Methods 152 cases of superficial urinary bladder cancer patients were randomly divided into two groups. Test group: Li Er where + cisplatin + radiotherapy; control group: cisplatin alone + radiotherapy. The recurrence rate and recurrence interval were compared between groups, the T cell subsets and white blood cells before and after treatment were compared. Results The recurrence rate and recurrence interval of test group and control group were significantly different (all P <0.05). The NK cell count and CD4 / CD8 count in experimental group before and after treatment were significantly different (all P <0.05), and were significantly higher than those before treatment in the experimental group. The total number of leukocytes in the control group before and after treatment was significantly different (P <0.05) , After treatment was significantly lower than before treatment. Conclusion Li Er Fan can not only kill tumor cells but also have the effect of immune resuscitation and synergistic effect with other immune factors and chemotherapeutic drugs in the body. In the comprehensive treatment of bladder urothelial carcinoma, it is a safe and effective chemotherapy combination Drug choice.