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测定肺结节病患者支气管肺泡灌洗液中血管紧张素转化酶(BALF-ACE)的水平。结果显示,活动性结节病的BALF-ACE水平明显高于对照组(P<0.05)。相关性分析表明,BALF-ACE与支气管肺泡灌洗液中淋巴细胞百分率有明显正相关(γ=0.8723,P<0.01)。提示BALF-ACE在肺结节病的病理机制中起着重要作用,并可作为诊断肺结节病的一项敏感的生物学指标。
To determine the level of angiotensin-converting enzyme (BALF-ACE) in bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis. The results showed that active sarcoidosis BALF-ACE levels were significantly higher than the control group (P <0.05). Correlation analysis showed that BALF-ACE and bronchoalveolar lavage fluid lymphocyte percentage was positively correlated (γ = 0.8723, P <0.01). These results suggest that BALF-ACE plays an important role in the pathogenesis of pulmonary sarcoidosis and can be used as a sensitive biological indicator in the diagnosis of pulmonary sarcoidosis.