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内膜增生是血管损伤后动脉重塑过程中普遍存在的现象。血管平滑肌细胞(vascular smooth muscle cells,VSMCs)的增殖、迁移、表型转换是血管损伤性疾病高血压、动脉粥样硬化、血管成形术后再狭窄等的共同病理生理学过程。干扰素调节因子(interferon regulatory factors,IRFs)是一类能对干扰素基因表达起到免疫调节作用的转录因子。近来研究发现,其在血管损伤病理过程具有调节作用,其中IRF1与细胞生长、分化和损伤密切相关,IRF3与IRF7可以抑制新生内膜的形成,而IRF8和IRF9则促进VSMCs增殖、迁移及血管内膜增生。本文重点介绍了IRFs的结构特征、信号途径及在血管重塑过程中作为新型调控因子的功能。
Intimal hyperplasia is a common phenomenon in arterial remodeling after vascular injury. Proliferation, migration and phenotypic change of vascular smooth muscle cells (VSMCs) are common pathophysiological processes of vascular injury such as hypertension, atherosclerosis and restenosis after angioplasty. Interferon regulatory factors (IRFs) are a class of transcription factors that play an immunomodulatory role in interferon gene expression. Recent studies have found that it has a regulatory role in the pathological process of vascular injury, of which IRF1 and cell growth, differentiation and injury are closely related to IRF3 and IRF7 can inhibit the formation of neointima, while IRF8 and IRF9 promote VSMCs proliferation, migration and intravascular Membrane hyperplasia. This article highlights the structural features of IRFs, their signaling pathways, and their function as novel regulators in vascular remodeling.