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用肾上腺皮质激素造成“阳虚”动物模型法观察健男春灌胃（ig）对小鼠及大鼠阳虚模型恢复的影响．小鼠给予健男春高、中、低剂量（5．0，2．5和1.25g／kg·d-1×7d）不能对抗强的松龙5mg／kg·d-1×7d所致肾上腺、胸腺、脾脏的萎缩，但能促进停用强的松龙后的肾上腺加快恢复．在停用强的松龙后d10，继续应用健男春，高、中、低剂量组肾上腺重量（mg／10g体重）分别为2．88±S0．56，2．61±s0.58和2.67±s0.66，与阳虚加生理盐水组（1．89±s0．19）相比有显著差别（P＜0.05）。阳性对照药男宝显示阳性药效。健男春对阳虚大鼠的作用与其对小鼠的作用相似，亦能促进萎缩的肾上腺加快恢复。停用强的松龙后d9健男春（2．0和1.0g/kg组肾上腺重量（mg／100g体重）分别为25．22±s3.90和22．73±S4。与单纯阳虚组（13．68±s3.13）比较明显增加（P＜0．001），男宝亦显示阳性药效。增大的肾上腺病理学检查见其切面皮质增厚，光镜下见皮质有早期结节样增生。此外，健男春尚可促进阳虚小鼠睡眠，使成巴比安纳引起睡眠时间明显延长（P＜0．05）。
The effects of Jiannanchun gavage (ig) on recovery of mouse and rat yang-deficiency model were observed with adrenocortical hormone-induced “deficiency” animal model. High doses (5.0, 2.5, and 1.25 g/kg.d-1.times.7 d) of the mice given to the male can not be counteracted by the adrenal glands of prednisolone, 5 mg/kg.d-1.times.7 d. The atrophy of the thymus and spleen, but can promote the recovery of adrenal after the withdrawal of prednisolone. After stopping prednisolone for d10, continue to apply Jiannanchun. Adrenal gland weights (mg/10g body weight) in the high, middle, and low dose groups were 2.88±S0.56, 2.61±s 0.58, and 2.67±, respectively. S0.66 was significantly different from the yang deficiency plus saline group (1.89±s0.19) (P<0.05). Positive control drug male treasure shows positive effect. The effect of Jiannanchun on rats with Yang deficiency is similar to that of mice, and it also promotes the atrophy of the adrenal gland to accelerate recovery. After withdrawal of prednisolone, d9 Jiannanchun (adrenal weight (mg/100g body weight) in the 2.0 and 1.0 g/kg groups was 25.22±s3.90 and 22.73±S4, respectively. Compared with the pure Yang deficiency group ( 13.68±s3.13) increased significantly (P<0.001), and male treasure also showed positive effect. The enlarged adrenal pathology showed thickening of the cortical surface, and there were early nodules in the cortex under light microscope. Hyperplasia.In addition, Jiannanchun can promote sleep in Yang-deficient mice, which can lead to a prolonged sleep time (P<0.05).