论文部分内容阅读
目的探讨血清肿瘤坏死因子-α(TNF-α)、高迁移率族蛋白-1(HMGB-1)、特异性烯醇化酶(NSE)在新生儿窒息早期诊断中的价值。方法根据Apgar评分标准将87例新生儿窒息患儿分为轻度窒息组(48例)以及重度窒息组(39例),60例同期出生的正常新生儿作为对照组;对3组血清TNF-α、HMGB-1、NSE水平进行了72 h内动态监测,并进行了组间比较、动态趋势分析、受试者工作特征曲线(ROC曲线)分析。结果 3种因子组间差异有统计学意义(均P<0.05),均为重度窒息组高于轻度窒息组,轻度窒息组高于对照组。动态监测结果表明24 h时3种因子在血液中均达到峰值,之后逐渐下降。ROC曲线显示,24 h时各指标对新生儿窒息的诊断具有最高的线下面积。结论 TNF-α、HMGB-1、NSE这3种血液因子均可作为新生儿窒息的检测指标,在出生后24 h最为准确。
Objective To investigate the value of serum tumor necrosis factor-α (TNF-α), high mobility group box-1 (HMGB-1) and specific enolase (NSE) in early diagnosis of neonatal asphyxia. Methods 87 neonates with asphyxia were divided into mild asphyxia group (48 cases) and severe asphyxia group (39 cases) according to Apgar score criteria. Sixty normal newborns born at the same period were used as control group. The levels of serum TNF- α, HMGB-1 and NSE were monitored within 72 hours. The comparison among groups, dynamic trend analysis and receiver operating characteristic curve (ROC curve) analysis were performed. Results There was significant difference among the three factors (all P <0.05), which were higher in severe asphyxia group than in mild asphyxia group and higher in mild asphyxia group than in control group. Dynamic monitoring results showed that all three factors peaked in blood at 24 h, then decreased gradually. The ROC curve showed that each index had the highest area under the line for the diagnosis of neonatal asphyxia at 24 h. Conclusion The three blood factors, TNF-α, HMGB-1 and NSE, can be used as indicators of neonatal asphyxia, most accurately at 24 h after birth.