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葡萄糖转运调节在子宫内膜蜕膜化过程中起着重要作用。采用免疫组化方法检测9例增生期子宫内膜、11例分泌期子宫内膜、16例早期妊娠流产的蜕膜组织中葡萄糖转运蛋白异构体1(GLUT1)表达,用RNA酶保护测定法检测增生期(14例)、分泌早期(15～18 d,7例)、中期(20～24 d,8例)、晚期(25～28 d,6例)的子宫内膜及妊娠7～8周、9～10周蜕膜组织(各5例)中GLUT1 mRNA表达水平。结果:免疫组化提示,增生期及分泌早期子宫内膜无GLUT1阳性着色,蜕膜组织中度阳性着色,胎盘组织呈强阳性着色;GLUT1 mRNA在增生晚期及分泌早期子宫内膜呈低水平表达,分泌晚期表达量增加近2倍,在妊娠早期,尤其是9～10周蜕膜组织中表达量
Glucose transport regulation plays an important role in endometrial decidualization. Immunohistochemistry was used to detect the expression of GLUT1 in 9 cases of proliferative endometrium, 11 cases of secretory endometrium and 16 cases of decidua in early pregnancy. The expression of glucose transporter 1 (GLUT1) The endometrium and endometrium were detected in 14 patients with early stage of exacerbation (15-18 days, 7 cases), mid-term (20-24 days, 8 cases) and late stage (25-28 days, 6 cases) Weeks, 9 to 10 weeks decidual tissue (each 5) in the GLUT1 mRNA expression levels. Results: Immunohistochemistry showed no positive staining of GLUT1 in the proliferative phase and early secretory endometrium, moderate staining in the decidua tissue, strong positive staining in the placenta, and low expression of GLUT1 mRNA in the late stage of proliferative and early secretory endometrium , The secretion of late expression increased nearly 2-fold in early pregnancy, especially in 9 to 10 weeks the expression of decidual tissue