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[Objective] To study the serum pharmacochemistry of extract from Citrus reticulata ’Chachi’ Peel. [Method] Based on the establishment of HPLC fingerprints of extract of C. reticulata peel, the constituents absorbed into blood were determined by comparing HPLC fingerprints of the methanol extract of C. reticulata peel, medicated plasma with extract of C. reticulata peel and blank serum. [Result] Seventeen compounds absorbed into blood were found in medicated serum, among which five were original constituents of extract from C. reticulata peel and the other might be metabolites of the original constituents. [Conclusion] Polymethoxylated flavones, nobiletin and hesperetin which are absorbed into blood might be bioactive components of extract of C. reticulata peel. Further studies on them will help clarify the bioactive constituents and functional food factors of extract from C. reticulata peel.
[Objective] To study the serum pharmacochemistry of extract from Citrus reticulata ’Chachi’ Peel. [Method] Based on the establishment of HPLC fingerprints of extract of C. reticulata peel, the constituents absorbed into blood were determined by HPLC fingerprints of the methanol extract of C. reticulata peel, medicated plasma with extract of C. reticulata peel and blank serum. [Result] Seventeen compounds were absorbed into blood were found in medicated serum, among which five were original constituents of extract from C. reticulata peel and the other might be metabolites of the original constituents. [Conclusion] Polymethoxylated flavones, nobiletin and hesperetin which are absorbed into blood might be bioactive components of extract of C. reticulata peel. Further studies on them will help clarify the bioactive constituents and functional food factors of extract from C. reticulata peel.