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[目的]评价卵巢癌患者外周血Th1/Th2细胞因子表达与复发的相关性。[方法]分析58例卵巢癌患者治疗前的外周血Th1类细胞因子(IFN-γ、IL-2)和Th2类细胞因子(IL-4、IL-5、IL-10)的表达水平与肿瘤复发的关系。采用SPSS16.0统计软件,对5种细胞因子水平下的无进展生存率(progression-freesurvival,PFS)作Kaplan-Meier法生存分析。[结果]58例卵巢癌的1年PFS为91.0%,3年PFS为67.7%,中位PFS为47个月(95%CI:43.864～50.136)。IL-4正常组1年、3年PFS分别为100%和80.0%,IL-4异常组分别为75.9%和43.0%,两组比较差异有统计学意义(χ2=4.465,P=0.035)。[结论]卵巢癌患者血清Th1/Th2细胞因子检测,可作为判断肿瘤转移、预测预后的重要工具之一。
[Objective] To evaluate the correlation between Th1 / Th2 cytokine expression and recurrence in peripheral blood of patients with ovarian cancer. [Methods] The expressions of Th1 cytokines (IFN-γ, IL-2) and Th2 cytokines (IL-4, IL-5 and IL-10) in peripheral blood of 58 patients with ovarian cancer before treatment were analyzed. Relapse relationship. Kaplan-Meier method was used to analyze progression-free survival (PFS) at five cytokines levels using SPSS16.0 statistical software. [Results] The one-year PFS of 58 cases of ovarian cancer was 91.0%, the 3-year PFS was 67.7%, and the median PFS was 47 months (95% CI: 43.864-50.136). The 1-year and 3-year PFS in IL-4 normal group were 100% and 80.0%, respectively. The abnormal IL-4 levels were 75.9% and 43.0% in the normal group, respectively. There was significant difference between the two groups (χ2 = 4.465, P = 0.035). [Conclusion] The detection of serum Th1 / Th2 cytokines in patients with ovarian cancer can be used as one of the important tools to predict the prognosis of tumor metastasis.