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在发育生物学领域中,微环境对早期胚胎纽胞的分化,对造血系统干细胞的分化都能产生影响,这已是人所共知的事实。小鼠胚胎性癌细胞(EC细胞)是一种研究细胞恶变和细胞分化很好的材料,它可以在某些品系小鼠中自发地产生,也可由小鼠早期胚胎细胞或原始生殖嵴细胞经异位移植而获得,但移植的位置不同,生瘤率也不同。EC细胞一般分为无能和多能性两种:无能EC细胞如F9在体内接种后不能分化为各种体细胞,保持着癌细胞恶性生长的特点,而多能EC细胞接种到
In the field of developmental biology, it is well known that the differentiation of newborns in early embryos and the differentiation of hematopoietic stem cells in the microenvironment affect the early embryos. Mouse embryonic carcinoma cells (ECs), a well-studied material for the study of cell malignant transformation and cell differentiation, can be produced spontaneously in some strain mice and also by mouse early embryonic or primitive germ crest cells Ectopic transplantation and obtained, but the location of transplantation, the tumor rate is also different. EC cells are generally divided into two types of incompetence and pluripotency: Incomplete EC cells such as F9 can not differentiate into somatic cells after inoculation in vivo, and maintain the malignant growth characteristics of cancer cells, while multipotential EC cells are seeded into