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作者将146例乳腺转移性癌患者分成5组:Ⅰ组53例,阿霉素治疗前、后胸片正常;Ⅱ组7例,临床和放射学有充血性心肌病的表现;Ⅲ组35例,据阿霉素治疗前、后胸膜渗出量,再分成Ⅲ_a 16例,在化疗前仅有小量或无胸膜渗出,但在治疗中出现明显的胸膜渗出,Ⅲ_b 16例,在化疗初已有大量胸膜渗出,随着阿霉素的疗程,其渗出量逐渐增多,Ⅲ_c 3例,其渗出量在治疗前后无显著变化;Ⅳ组28例,有肺实质转移癌;Ⅴ组23例,照射后有明显的肺纤维化。 146例在接受阿霉素治疗前、中、后均检查心电图二次以上,平均每例患者查心电图6.47次。心电图中最有意义的是QRS电压幅度的改变。Ⅰ组QRS电压平均降低7.3%。Ⅱ组患者化疗后,QRS电压显著降低,平均降低28.6%,在充血性心衰发作时,QRS
The authors divided 146 patients with metastatic breast cancer into 5 groups: 53 patients in group I, normal chest radiographs before and after treatment with adriamycin; 7 patients in group II with clinical and radiologic signs of congestive cardiomyopathy; 35 patients in group III , According to adriamycin treatment before and after the pleural exudation, divided into III_a 16 cases, only a small amount or no pleural effusion before chemotherapy, but in the treatment of obvious pleural effusion, III_b 16 cases, in the chemotherapy At the beginning, a large number of pleural effusions have been exuded. With the doxorubicin treatment, the amount of exudation gradually increased. In 3 cases of III_c, the amount of exudation did not change significantly before and after treatment; in group IV, there were 28 cases of metastatic carcinoma of the lung parenchyma; In group 23, there was significant pulmonary fibrosis after irradiation. In 146 patients, ECG was examined twice or more before, during, and after treatment with doxorubicin. The mean electrocardiogram was 6.47 times per patient. The most significant of the electrocardiograms is the change in QRS voltage amplitude. Group I QRS voltage decreased by an average of 7.3%. QRS voltage was significantly lower in group II patients after chemotherapy, with an average decrease of 28.6%. QRS was the episode of congestive heart failure.