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促胃液素瘤(Gastrinoma)、即Zollinger-Ellison氏综合症、亦称胰腺非β细胞腺瘤、胰源性溃疡症群。是一种胰岛的非β细胞肿瘤或转移至其他脏器中的促胃液素瘤,分泌大量促胃液激素,而引起严重的上消化道溃疡,继而产生一系列严重的并发症的一种疾病。 1955年Zollinger和Ellison首先报导2例本病。指出此病是由于肿瘤分泌一种激素刺激胃酸大量分泌所致。总结为:原发性溃疡发生于非常见部位,如十二指肠2,3部和上段空肠;或作胃各种术式(除全胃切除术)后随即发生复发性吻合口溃疡;非药物和外科手术所能控制的胃液高度分泌;胰腺的非β细胞肿瘤。为此明确了早在1948年Poth等人以及
Gastrinoma, the Zollinger-Ellison syndrome, also known as pancreatic non-beta cell adenoma, pancreatic ulcer group. It is a non-beta cell tumor of the pancreatic islets or a gastrin tumor that metastasizes to other organs, secretes a large amount of gastric-stimulating hormone, causes a severe upper digestive ulcer, and then produces a series of serious complications. In 1955 Zollinger and Ellison first reported two cases of the disease. It was pointed out that the disease was caused by the tumor secreting a hormone that stimulated the secretion of large amounts of gastric acid. Summed up as follows: primary ulcers occur in uncommon sites such as the duodenum 2, 3 and the upper jejunum; or recurrent anastomotic ulcers occur after various surgical procedures for the stomach (except total gastrectomy); Highly secreted gastric juices that can be controlled by drugs and surgery; non-beta cell tumors of the pancreas. To this end it was clear that as early as 1948 Poth et al.